Structural Biology Services
Avail our high-quality structural biology services to support your structure-based drug discovery from gene to protein co-crystal structures at prices starting as low as $14/hour
Are you looking for a highly-experienced structural biology team to support your structure-based drug discovery right from gene to protein co-crystal structures of small molecule compounds using x-ray crystallography at high resolution? Are you looking for a structural biology team to provide protein expression and protein purification services? If so, you have come to the right place.
Flatworld Solutions is a leading structural biology service provider and provides high-quality structural biology solutions to a global clientele. We provide a full package of services, right from construct design, custom protein production, protein characterization, and gene cloning and expression to x-ray diffraction data collection, crystal hit screening and optimization, and structure solving. We also offer cells expressing target proteins and recombinant proteins for functional assays.
Our Structural Biology Services
We are a leading structural biology research consultant as well as a structural biology services company and provide a wide range of services that help you accelerate your small-molecule drug discovery process. We have 20 years of experience in providing structural biology services to a global clientele.
Our structural biology services include -
X-ray Structural Studies Services
The team at Flatworld Solutions has time and again demonstrated its strength in protein engineering to cater to the needs of crystallization. We have also designed multiple constructs for gene-to-structure projects and have worked on numerous different protein targets and delivered several co-crystal structures. Our services include -
Electron Density Maps
Synchrotron beam services
Structural determination
Crystal hit optimization (additive/detergent screening, sparse matrix grid)
Diffraction data collected using in-house x-rays
Structure Interpretation
Ligand binding analysis
Advice on medicinal chemistry design
Protein (in the presence of ligand or apo) crystallization screening using commercial kits
Structural analysis
Biophysical Analysis Services
Our biophysical analysis services including -
Measurement of the melting temperature of proteins
Thermal shift assay processing
Identifying appropriate protein storage buffers
Mass spectrometry including intact mass measurement and protein identification
Identification and assessment of compounds binding with proteins
Surface plasmon resonance, including Kon, KD, and Koff in a single injection, screening of low Mw fragments, use of Pioneer FE system, and analysis of irreversible inhibition by Kinact/Kl or Kon Cc.
Recombinant Protein Expression and Purification Services
We are one of the top structural biology services firms and provide high-quality proteins for structural and biophysical studies, high throughput screening, and enzymatic assays. Our services include -
High throughput screening in different expression systems such as mammalian cells, baculo-insect, and E. coli.
Designing constructs
Refolding from inclusion bodies
Cell culture within flasks and wave bags
Size exclusion chromatography services
Co-expression with chaperons or in the regulatory domain
Various chromatography stages using highly-efficient AKTA purification systems
Expression optimization and scale-up
Ion exchange chromatography services
Affinity chromatography services
Purity > 95% (on SDS-PAGE)
Protein Production and Crystallization Services
At Flatworld Solutions, our protein production and crystallization services cover purification, cloning, crystallization, and expression of target proteins. We make use of modern and high-quality laboratory equipment to provide all our services. Our services include -
Robotic nanolitre-scale screening and imaging
Co-crystallization of ligands
Optimization of conditions for crystal growth
Screening with known ligands
Fragment Screening Services
We have in-house libraries and resources designed with chemo-genomic tools that allow us to more accurately identify critical fragment leads.
Stable Cell Lines Generation Services
We handle target genes that cover kinases, ion channels, GPCRs, carboxylases, etc. to generate stables within different cell backgrounds through the use of lentiviral-mediated or plasmid-mediated transfection.
Library Services
We are a leading structural biology service providing company and our in-house library consists of a high-quality collection of important proteins that can be used for rapid x-ray structure determination.
X-ray Crystallography Services
We perform high-resolution structure determination using X-ray crystallography to support both integrated and stand-alone drug discovery projects.
Why Outsource Structural Biology Services to Flatworld Solutions?
As one of the top structural biology services firms, there are a whole host of reasons to choose us, including
High-quality Services
We provide only the highest-quality services, and this is one way in which we stand out from our competition. We are also ISO-certified, ensuring that we deliver only top-quality services.
World-class Infrastructure
All our structural biology researchers have access to world-class laboratory facilities and office spaces. Our teams also use the latest and best scientific equipment and tools.
Affordable Pricing Options
We make structural biology research much more affordable and convenient. However, we still ensure that our output is of the highest quality.
Experienced Team
Our structural biology team comprises members that are highly experienced and qualified. This helps us deliver only top-quality services.
Quick Turnaround Time
All our structural biology services are provided as quickly as possible to ensure that no time is wasted.
Software and Equipment
When you offshore structural biology research services to us, you get access to a team of dedicated and qualified research professionals that use cutting-edge software tools and technologies to deliver outstanding results.
Data Security
Our ISO/IEC 27001:2022 ISMS-certification demonstrates that we are committed to adhering to the strictest global standards related to data security. Only researchers that have signed strict NDAs will be allowed to access your data.
Single Point of Contact
When you outsource to us, you will not need to spend any time waiting to get your queries resolved. We will assign a project manager that will always be available during your work hours to answer your queries (if any).
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Outsource Structural Biology Services to Flatworld Solutions
Flatworld Solutions is a pioneer in providing affordable and high-quality structural biology services. We have a team of dedicated, experienced, and qualified professionals that will go the extra mile to provide the best services possible. We also use the latest scientific equipment and tools to provide superior results to our clients.
If you are looking for high-quality and affordable structural biology services, get in touch with us today.
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Our Customers
Case Studies
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Flatworld Helped a US-based Healthcare Client Develop a Forecasting Model
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Flatworld Provides Online and Offline Research Support to Evaluate Competition
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FWS Provided Key Opinion Leaders (KOL) Profiling to a Top UK-based Med Firm
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FWS Provided a Detailed Porter Analysis and Web Research to a Leading US Technology Consulting Company
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Flatworld Solutions Provided Research Services to Top Hospitality Consulting Solutions Provider
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USA
Flatworld Solutions
116 Village Blvd, Suite 200, Princeton, NJ 08540
PHILIPPINES
Aeon Towers, J.P. Laurel Avenue, Bajada, Davao 8000
KSS Building, Buhangin Road Cor Olive Street, Davao City 8000