Structural Biology Services

Avail our high-quality structural biology services to support your structure-based drug discovery from gene to protein co-crystal structures at prices starting as low as $14/hour

Are you looking for a highly-experienced structural biology team to support your structure-based drug discovery right from gene to protein co-crystal structures of small molecule compounds using x-ray crystallography at high resolution? Are you looking for a structural biology team to provide protein expression and protein purification services? If so, you have come to the right place.

Flatworld Solutions is a leading structural biology service provider and provides high-quality structural biology solutions to a global clientele. We provide a full package of services, right from construct design, custom protein production, protein characterization, and gene cloning and expression to x-ray diffraction data collection, crystal hit screening and optimization, and structure solving. We also offer cells expressing target proteins and recombinant proteins for functional assays.

Our Structural Biology Services

We are a leading structural biology research consultant as well as a structural biology services company and provide a wide range of services that help you accelerate your small-molecule drug discovery process. We have 20 years of experience in providing structural biology services to a global clientele.

Our structural biology services include -

1. X-ray Structural Studies Services

   

   The team at Flatworld Solutions has time and again demonstrated its strength in protein engineering to cater to the needs of crystallization. We have also designed multiple constructs for gene-to-structure projects and have worked on numerous different protein targets and delivered several co-crystal structures. Our services include -

   • Electron Density Maps
   • Structure Interpretation
   • Synchrotron beam services
   • Ligand binding analysis
   • Structural determination
   • Advice on medicinal chemistry design
   • Crystal hit optimization (additive/detergent screening, sparse matrix grid)
   • Protein (in the presence of ligand or apo) crystallization screening using commercial kits
   • Diffraction data collected using in-house x-rays
   • Structural analysis

2. Fragment Screening Services

   

   We have in-house libraries and resources designed with chemo-genomic tools that allow us to more accurately identify critical fragment leads.

3. Biophysical Analysis Services

   

   Our biophysical analysis services including -

   • Measurement of the melting temperature of proteins
   • Mass spectrometry including intact mass measurement and protein identification
   • Thermal shift assay processing
   • Identification and assessment of compounds binding with proteins
   • Identifying appropriate protein storage buffers
   • Surface plasmon resonance, including Kon, KD, and Koff in a single injection, screening of low Mw fragments, use of Pioneer FE system, and analysis of irreversible inhibition by Kinact/Kl or Kon Cc.

4. Recombinant Protein Expression and Purification Services

   

   We are one of the top structural biology services firms and provide high-quality proteins for structural and biophysical studies, high throughput screening, and enzymatic assays. Our services include -

   • High throughput screening in different expression systems such as mammalian cells, baculo-insect, and E. coli.
   • Various chromatography stages using highly-efficient AKTA purification systems
   • Designing constructs
   • Expression optimization and scale-up
   • Refolding from inclusion bodies
   • Ion exchange chromatography services
   • Cell culture within flasks and wave bags
   • Affinity chromatography services
   • Size exclusion chromatography services
   • Purity > 95% (on SDS-PAGE)
   • Co-expression with chaperons or in the regulatory domain

5. Protein Production and Crystallization Services

   

   At Flatworld Solutions, our protein production and crystallization services cover purification, cloning, crystallization, and expression of target proteins. We make use of modern and high-quality laboratory equipment to provide all our services. Our services include -

   • Robotic nanolitre-scale screening and imaging
   • Optimization of conditions for crystal growth
   • Co-crystallization of ligands
   • Screening with known ligands

6. Stable Cell Lines Generation Services

   

   We handle target genes that cover kinases, ion channels, GPCRs, carboxylases, etc. to generate stables within different cell backgrounds through the use of lentiviral-mediated or plasmid-mediated transfection.

7. Library Services

   

   We are a leading structural biology service providing company and our in-house library consists of a high-quality collection of important proteins that can be used for rapid x-ray structure determination.

8. X-ray Crystallography Services

   

   We perform high-resolution structure determination using X-ray crystallography to support both integrated and stand-alone drug discovery projects.

Other Services You Can Benefit From

Why Outsource Structural Biology Services to Flatworld Solutions?

As one of the top structural biology services firms, there are a whole host of reasons to choose us, including -

• High-quality Services

  We provide only the highest-quality services, and this is one way in which we stand out from our competition. We are also ISO-certified, ensuring that we deliver only top-quality services.

• World-class Infrastructure

  All our structural biology researchers have access to world-class laboratory facilities and office spaces. Our teams also use the latest and best scientific equipment and tools.

• Affordable Pricing Options

  We make structural biology research much more affordable and convenient. However, we still ensure that our output is of the highest quality.

• Experienced Team

  Our structural biology team comprises members that are highly experienced and qualified. This helps us deliver only top-quality services.

• Quick Turnaround Time

  All our structural biology services are provided as quickly as possible to ensure that no time is wasted.

• Software and Equipment

  When you offshore structural biology research services to us, you get access to a team of dedicated and qualified research professionals that use cutting-edge software tools and technologies to deliver outstanding results.

• Data Security

  Our ISO/IEC 27001:2022 ISMS-certification demonstrates that we are committed to adhering to the strictest global standards related to data security. Only researchers that have signed strict NDAs will be allowed to access your data.

• Single Point of Contact

  When you outsource to us, you will not need to spend any time waiting to get your queries resolved. We will assign a project manager that will always be available during your work hours to answer your queries (if any).

Client Success Stories

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Our team developed a highly efficient and effective patient dashboard for a pharmaceutical company based in Hong Kong.

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Swedish marketing intelligence firm required detailed research on online healthcare from 17 different countries. We provide high-quality services quickly.

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Outsource Structural Biology Services to Flatworld Solutions

Flatworld Solutions is a pioneer in providing affordable and high-quality structural biology services. We have a team of dedicated, experienced, and qualified professionals that will go the extra mile to provide the best services possible. We also use the latest scientific equipment and tools to provide superior results to our clients.

If you are looking for high-quality and affordable structural biology services, get in touch with us today.